
- 姓 名:
- 邵楓
- 職 稱:
- 副教授
- 研究領(lǐng)域:
- 心理神經(jīng)免疫學(xué) 擬精神分裂癥動(dòng)物模型的認(rèn)知障礙及其中樞機(jī)制研究
- 通信地址:
- 北京大學(xué)王克楨樓 100080
- 電子郵件:
- [email protected]
北京大學(xué)心理學(xué)系(現(xiàn)北京大學(xué)心理與認(rèn)知科學(xué)學(xué)院)副教授,博士
1997 年 9 月 -2000 年 7 月 中國科學(xué)院心理研究所(生物心理學(xué)) 博士
2000 年 7 月 -2003 年 8 月 北京大學(xué)心理學(xué)系(現(xiàn)北京大學(xué)心理與認(rèn)知科學(xué)學(xué)院) 講師
2003 年 8 月至今 北京大學(xué)心理學(xué)系(現(xiàn)北京大學(xué)心理與認(rèn)知科學(xué)學(xué)院) 副教授
科研項(xiàng)目
1、青少期社會(huì)隔離誘發(fā)大鼠擬精神分裂癥認(rèn)知功能障礙的BDNF表觀遺傳學(xué)機(jī)制研究,國家自然科學(xué)基金會(huì)面上項(xiàng)目,80萬,2015.1-2018.12,主持
2、青少年階段社會(huì)隔離干擾中腦多巴胺系統(tǒng)神經(jīng)發(fā)育并誘發(fā)成年大鼠認(rèn)知障礙的分子機(jī)制研究, 國家自然科學(xué)面上基金, 35萬, 2011.1-2013.12, 主持
3、早期隔離應(yīng)激誘導(dǎo)的擬精神分裂癥顛倒學(xué)習(xí)障礙的神經(jīng)生物學(xué)機(jī)制研究,國家自然科學(xué)面上基金,25萬,2007年1-2009年12,主持
4、抑郁癥和精神分裂癥的基因與環(huán)境相互作用機(jī)理研究 - 疾病的腦高級(jí)功能障礙(子課題), “國家重點(diǎn)基礎(chǔ)研究發(fā)展計(jì)劃資助(973)”及課題編號(hào)2007CB512306, 2007-2012
5、擬精神分裂癥動(dòng)物模型的深入化研究,國家自然科學(xué)青年基金,18萬,2002年1-2005年12,主持
6、情緒過程、神經(jīng)生理機(jī)制與教育干預(yù),教育部科學(xué)技術(shù)重點(diǎn)項(xiàng)目,1.5萬,2002-2005,參與??
1 ,擬精神分裂癥動(dòng)物模型的認(rèn)知障礙及其中樞機(jī)制研究
2 ,心理神經(jīng)免疫學(xué)研究
英文論著
Xu, H., Wang, JS., Zhang, K., Zhao, M., Ellenbroek, B., Shao,F*., Wang,WW. (2018). Effects of adolescent social stress and antidepressant treatment on cognitive inflexibility and Bdnf epigenetic modifications in the mPFC of adult mice. Psychoneuroendocrinology, 88,92-101.
Wang, Q., Shao,F*., Wang, WW. (2018). Region-Dependent Alterations in Cognitive Function and ERK1/2 Signaling in the PFC in Rats after Social Defeat Stress. Neural Plasticity, 2018, 9870985
Sun, L., Min, L., Li, M., Shao,F*., Wang, WW. (2018). Transcriptomic analysis reveals oxidative phosphorylation activation in an adolescent social isolation rat model. Brain Research Bulletin, 142, 304-312
Li, M., Sun, L., Du, W., Zhou, H., Shao,F*., Wang, WW. (2018). Chronic clozapine treatment improves the alterations of prepulse inhibition and BDNF mRNA expression in the medial prefrontal cortex that are induced by adolescent social isolation. Behavioral Pharmacology, (in press)
Sun, L., Min, L., Zhou, H., Li, M., Shao, F*. (2017). Adolescent social isolation affects schizophrenia-like behavior and astrocyte biomarkers in the PFC of adult rats. Behaviroal Brain Research, 333,258-266. (corresponding author)
Zhang, Y., Shao, F., Wang, Q., Xie, X., Wang, W.W. (2017). Neuroplastic Correlates in the mPFC Underlying the Impairment of Stress-Coping Ability and Cognitive Flexibility in Adult Rats Exposed to Chronic Mild Stress during Adolescence. Neural Plasticity, 10,1-10.
Tian, Y.L., Yang, CH.J., Shang, SH.J., Cai, Y.J., Deng, X.F., Zhang, J., Shao, F., et al. (2017). Loss of FMRP impaired hippocampal long-term plasticity and spatial learning in rats. Frontiers in Molecular Neuroscience, 10, 1-14
Li, M., Du W., Shao, F*., Wang, W.W. (2016). Cognitive dysfunction and epigenetic laterations of the BDNF gene are reduced by social isolation during early adolescence. Behav Brain Res, 313, 177-183. (corresponding author)
Zhang, F., Yuan, S., Shao, F., & Wang, W. (2016). Adolescent social defeat induced alterations in anxious behavior and cognitive flexibility in adult mice: effects of developmental stage and social condition. Frontiers in Behavioral Neuroscience, 10,149: 1-11.
Xu, H., Zhang, Y., Zhang, F., Yuan, S. N., Shao, F.,& Wang, W. (2016). Effects of Duloxetine Treatment on Cognitive Flexibility and BDNF Expression in the mPFC of Adult Male Mice Exposed to Social Stress during Adolescence. Front Mol Neurosci, 9, 95. doi: 10.3389/fnmol.2016.00095
Wang,Q., Shao, F*., Wang, W.W. (2015). Maternal separation produces alterations of forebrain brain-derived neurotrophic factor expression in differently aged rats. Frontiers in Molecular Neuroscience, 8, 1-8. (corresponding author)
Wu, J.J., Yu, CH.H., Tan, Y., Hou, ZH., Li, M., Shao, F*., Lu, X.X. (2015). Effects of prenatal exposure to silver nanoparticles on spatial cognition and hippocampal neurodevelopment in rats. Environmental Research, 138, 67-73. (corresponding author)
Wang, Q., Li, M., Du, W., Shao, F*., Wang, W.W. (2015). The different effects of maternal separation on spatial learning and reversal learning in rats. Behavioural Brain Research, 280, 16-23. (corresponding author)
Shao, S., Li, M., Du, W., Shao, F*., Wang, W.W. (2014). Galanthamine, an acetylcholine inhibitor, prevents prepulse inhibition deficits induced by adolescent social isolation or MK-801 treatment. Brain Research, 1589, 105-111. (corresponding author)
Luo, X., Yuan, S., Guan,X., Xie, X., Shao, F*., Wang,W. (2014). Juvenile stress affects anxiety-like behavior and limbic monoamines in adult rats. Physilogy and Behavior, 135, 7-16. (corresponding author)
Guan, X., Shao, F., Xie, X., Chen, L., Wang, W. (2014). Effects of aspirin on immobile and endocrine and immune changes in the forced swimming test: Comparison to fluoxetine and imipramine. Pharmacology Biochemistry and Behavior, 124, 361-366.
Li, M., Xue, X., Shao, S., Shao, F*., & Wang, W. (2013). Cognitive, emotional and neurochemical effects of repeated maternal separation in adolescent rats. Brain Research, 1518, 82-90. (corresponding author)
Xue, X., Shao, S., Li, M., Shao, F*., & Wang, W. (2013). Maternal separaton induces alterations of serotonergic system in different aged rats. Brain Research Bulletin, 95, 15-20. (corresponding author)
Shao, F., Han, X., Shao, S., & Wang W. (2013). Adolescent social isolation influcences cognitive function in adult rats. Neural Regeneration Research, 8(11), 1025-1030.
Xue, X., Shao, S., Wang, W., & Shao, F*. (2013). Maternal separation induces alterations in reversal learning and brain-derived neurotrophic factior expression in adult rats. Neuropsychobiology, 68, 243-249.(corresponding author)
Han, X., Li, N., Xue, X., Shao, F*., & Wang, W. (2012). Early social isolation disrupts latent inhibition and increases dopamine D2 receptor expression in the medial prefrontal cortex and nucleus accumbens of adult rats. Brain Research, 1447(0), 38-43. (corresponding author)
Han, X., Wang, W., Shao, F*., & Li, N. (2011). Isolation rearing alters social behaviors and monoamine neurotransmission in the medial prefrontal cortex and nucleus accumbens of adult rats. Brain Research, 1385, 175-181 (corresponding author)
Han, X., Li, N., Meng, Q., Shao F*., Wang, W (2011). Maternal immune activation impairs reversal learning and increases serum TNF-α in offspring. Neuropsychobiology, 64, 9-14 (corresponding author)
Meng, Q., Li, N., Han, X., Shao, F*., & Wang, W. (2011). Effects of adolescent social isolation on the expression of brain-derived neurotrophic factors in the forebrain. European Journal of Pharmacology,650, 229-232 (corresponding author)
Han, X., Wang, W., Xue X., Shao, F*., & Li, N. (2011). Brief social isolation in early adolescence affects reversal learning and forebrain BDNF expression in adult rats. Brain Research Bulletin,86,173-178 (corresponding author)
Luo,X, Shao, F.,Guan, X., Xie X., Wang, WW. Progress in the “brain-derived neurotrophic factor depression hypothesis”. Neural Regeneration Research, 2010,5(23): 1817-1824
Shao, F., Han, X., Li, N., & Wang, W. (2010). Adolescent chronic apomorphine treatment impairs latent inhibition and reduces prefrontal cortex mGluR5 receptor expression in adult rats.. European Journal of Pharmacology, 649(1-3), 202-205.
Meng, Q., Li, N., Han, X., Shao, F., & Wang, W. (2010). Peri-adolescence isolation rearing alters social behavior and nociception in rats. Neuroscience Letters, 480(1), 25-29. (corresponding author)
Shao F, Jin J, Meng QX, Liu M, Xie X, Lin WJ, Wang WW (2009). Pubertal isolation alters latent inhibition and DA in nucleus accumbens of adult rats. Physiol Behav, 98: 251-257
Jihuan Chen, Wenjuan Lin, Weiwen Wang, Feng Shao (2004). Enhancement of antibody production and expression of c-fos in the insular cortex in response to a conditioned stimulus after a single-trial learning paradigm. Behavioural Brain Research, 154: 557-565
Shao Feng, Lin Wenjuan, Wang Weiwen. (2003). The effect of emotional stress on the primary humoral immunity of rats. J of psychopharmacology, 17(2):153-157
Li Liang Shao Feng (2003). Impaired auditory sensorimotor gating: An animal model of schizophrenia. Chinese Science Bulletin, 48(19):2031-2037
Lin Wenjuan Wang Weiwen Shao Feng (2003). New animal model of emotional stress: Behavioral, neuroendocrien and immunological consequences. Chinese Science Bulletin, 48(15): 1565-1568
中文論著
王瓊,王瑋文,李曼,杜偉,邵楓*. 阻斷內(nèi)側(cè)前額葉皮質(zhì)TrkB受體對(duì)大鼠認(rèn)知和海馬BDNF表達(dá)的影響. 心理學(xué)報(bào), 2016, 48(5), 509-517. ( 通訊作者)
原三娜,羅曉敏,張帆,邵楓,王瑋文. 大鼠注意定勢(shì)轉(zhuǎn)移任務(wù)模型的深入研究:種系和檢測程序的影響. 心理學(xué)報(bào), 2014, 46, 1-9.
張帆, 雍武,邵楓,王瑋文.中樞肥大細(xì)胞在腦功能和行為調(diào)節(jié)中的作用. 心理科學(xué)進(jìn)展,2014, 22, 1-11.
薛曉芳,李曼,王瑋文,邵楓.母嬰分離的動(dòng)物模型及其神經(jīng)生物學(xué)機(jī)制.心理科學(xué)進(jìn)展,2013,21(6):990-998.(通訊作者)
謝希, 邵楓, 羅曉敏, 管西婷, 孟慶軒, 王瑋文.氟西汀和丙米嗪對(duì)應(yīng)激誘導(dǎo)的青幼期大鼠抑郁和焦慮樣行為的不同影響.中國神經(jīng)精神疾病雜志,2010,36(1):14-18
金暕,王瑋文,孟慶軒,劉美,邵楓.不同發(fā)育階段社會(huì)隔離對(duì)成年大鼠潛伏抑制的影響.北京大學(xué)學(xué)報(bào)(自然科學(xué)版), 2009,45(2):350-354
金暕,王瑋文,劉美,邵楓. 精神分裂癥社會(huì)隔離動(dòng)物模型的研究進(jìn)展. 中華行為醫(yī)學(xué)與腦科學(xué)雜志,2009,18(6): 568-570
王瑋文 邵楓 劉美 金簡 林文娟.慢性應(yīng)激損害大鼠信號(hào)逆反學(xué)習(xí)能力:一種新的T型水迷宮檢測方法.中國神經(jīng)精神疾病雜志, 2009, 15(1): 42-44
邵楓,王瑋文,劉美, 金暕. 精神分裂癥的潛伏抑制動(dòng)物模型. 心理科學(xué)進(jìn)展, 2008,16(3):392-398
邵楓,李量,王瑋文. 阿撲嗎啡注射對(duì)大鼠視覺線索辨別學(xué)習(xí)和逆反學(xué)習(xí)的影響. 中國行為醫(yī)學(xué)科學(xué), 2008, 17(3): 193-195
劉美, 王瑋文, 金暕,邵楓. 青春期阿撲嗎啡注射對(duì)大鼠潛伏抑制和高架十字迷宮行為的影響. 中國行為醫(yī)學(xué)科學(xué), 2008, 17(3): 196-198
王瑋文,謝希,邵楓. 早發(fā)性抑郁及其神經(jīng)基礎(chǔ). 心理科學(xué)進(jìn)展, 2008,16(3):411-417
劉美,王瑋文,邵楓. 不同種系大鼠潛伏抑制模型的建立與評(píng)價(jià). 中國行為醫(yī)學(xué)科學(xué),2007,16(7): 577-579
王瑋文,邵楓,林文娟. 不同時(shí)程應(yīng)激對(duì)大鼠行為、免疫和交感神經(jīng)系統(tǒng)反應(yīng)的影響.心理學(xué)報(bào),2007, 39(2): 292-298
王瑋文,邵楓,劉美,孫萌,林文娟. 慢性應(yīng)激對(duì)大鼠行為和免疫細(xì)胞熱休克蛋白70表達(dá)的影響. 心理學(xué)報(bào), 2007, 39(5): 500-510
王瑋文, 邵楓, 劉美, 林文娟. 老化,慢性應(yīng)激與免疫細(xì)胞熱休克蛋白70反應(yīng)抑制. 中國行為醫(yī)學(xué)科學(xué), 2007,16(10):951-953
王瑋文,邵楓,劉美,林文娟. 早期應(yīng)激對(duì)抑郁相關(guān)行為及神經(jīng)內(nèi)分泌反應(yīng)的長期影響. 心理科學(xué)進(jìn)展,2006,14(6):907-911
何淑嫦,牛僑,邵楓,王生.鋁染毒對(duì)元代培養(yǎng)神經(jīng)細(xì)胞線粒體氧化功能的損傷. 衛(wèi)生研究, 2005 (6):685-687
何淑嫦,邵楓,牛僑. 鋁染毒大鼠學(xué)習(xí)記憶和氨基酸類神經(jīng)遞質(zhì)的改變.中國行為醫(yī)學(xué)科學(xué) 2005(1):11-12
邵楓 李量 耿曉峰. 一次阿撲嗎啡注射對(duì)大鼠視覺辨別學(xué)習(xí)和工作記憶的影響. 中國行為醫(yī)學(xué)科學(xué),2004,13(1):5-7
邵楓 李量 耿曉峰. 早期應(yīng)激與精神分裂癥. 中國行為醫(yī)學(xué)科學(xué),2004,13(2):228-229
邵楓 何淑嫦 耿曉峰. 早期隔離應(yīng)激對(duì)大鼠視覺線索辨別學(xué)習(xí)和逆反學(xué)習(xí)的影響. 中國行為醫(yī)學(xué)科學(xué),2004,13(3):247-248
邵楓 林文娟 肖健. 交感神經(jīng)系統(tǒng)在應(yīng)激免疫調(diào)節(jié)中的作用. 心理學(xué)報(bào), 2003, 35(4):559-562
邵楓 林文娟. 情緒應(yīng)激免疫調(diào)節(jié)作用的中樞機(jī)制研究. 心理學(xué)報(bào), 2003,35(5):685-689
邵楓 林文娟 陳極寰. 慢性情緒應(yīng)激對(duì)大鼠行為的影響及變化趨勢(shì). 中國行為醫(yī)學(xué)科學(xué), 2003, 12(1): 5-7
邵楓 林文娟. 電擊信號(hào)應(yīng)激免疫調(diào)節(jié)作用的中樞機(jī)制研究. 中國行為醫(yī)學(xué)科學(xué), 2003, 12(2):137-139
李量 邵楓. 精神分裂癥的感覺運(yùn)動(dòng)門控障礙的動(dòng)物模型. 科學(xué)通報(bào)中文, 2003, 48(15):1603-1612
林文娟 王瑋雯 邵楓. 慢性情緒應(yīng)激對(duì)大鼠行為神經(jīng)內(nèi)分泌和免疫反應(yīng)的影響-一個(gè)新的情緒應(yīng)激模型. 科學(xué)通報(bào)中文, 2003, 48(9):926-929
邵楓,林文娟. 情緒應(yīng)激體液免疫調(diào)節(jié)作用的影響因素研究,心理學(xué)報(bào),2001,33(6):543-547
邵楓,林文娟,王瑋雯. 心理應(yīng)激的免疫抑制作用及其與神經(jīng)內(nèi)分泌反應(yīng)的相關(guān)性研究, 心理學(xué)報(bào),2001,33(1):43-47
邵楓,林文娟,王瑋雯,鄭麗. 電擊信號(hào)應(yīng)激對(duì)大鼠體液免疫及內(nèi)分泌功能的影響,心理學(xué)報(bào),2000,32(4):428-432
邵楓,林文娟. 外周交感神經(jīng)系統(tǒng)在情緒應(yīng)激體液免疫調(diào)節(jié)中的作用,中國行為醫(yī)學(xué)科學(xué),2001,10(5):401-404
邵楓, 林文娟, 王瑋雯. 情緒應(yīng)激對(duì)大鼠體液免疫功能的影響及有關(guān)機(jī)制研究, 基礎(chǔ)醫(yī)學(xué)與臨床, 2002年1月 第22卷(增刊) 41頁
邵楓, 王瑋雯,林文娟. 兩種情緒應(yīng)激模式免疫調(diào)節(jié)腦機(jī)制的比較研究,基礎(chǔ)醫(yī)學(xué)與臨床, 2002年1月 第22卷(增刊) 45頁
鄭麗,林文娟,邵楓. 對(duì)體液免疫反應(yīng)的條件反射性調(diào)節(jié),心理科學(xué),2002,25(1):27-30
陳極寰,林文娟,邵楓. 條件反射性抗體反應(yīng)增強(qiáng)的動(dòng)態(tài)分析-以O(shè)VA為非條件刺激物,心理學(xué)報(bào), 2003, 35(2):261-265
邵楓,林文娟,王瑋雯,鄭麗. 電擊信號(hào)應(yīng)激對(duì)大鼠體液免疫及內(nèi)分泌功能的影響,心理學(xué)報(bào),2000,32(4):428-432