姓　　名：
田永路
職　　稱：
助理研究員
研究領(lǐng)域：
神經(jīng)精神疾病 動(dòng)物模型行為學(xué)評(píng)估
聯(lián)系電話：
010-62767844-215
通信地址：
北京大學(xué)實(shí)驗(yàn)動(dòng)物中心A座副樓204室，100871
電子郵件：
[email protected]

田永路博士于2008年畢業(yè)于河北農(nóng)業(yè)大學(xué)動(dòng)物科技學(xué)院，獲得農(nóng)學(xué)學(xué)士；2012年畢業(yè)于中國(guó)農(nóng)業(yè)大學(xué)動(dòng)物科學(xué)技術(shù)學(xué)院，獲得農(nóng)業(yè)推廣碩士；2019年畢業(yè)于北京大學(xué)前沿交叉學(xué)科研究院，獲得理學(xué)博士。2008年至2018年任北京大學(xué)實(shí)驗(yàn)動(dòng)物中心獸醫(yī)師。2019年至2022年在北京大學(xué)生命科學(xué)學(xué)院完成博士后訓(xùn)練。2022年3月起任北京大學(xué)心理與認(rèn)知科學(xué)學(xué)院助理研究員、IDG麥戈文腦科學(xué)研究所Co-PI（于翔教授課題組）。

主持科研項(xiàng)目：

  • 中國(guó)博士后科學(xué)基金, 自由探索性基礎(chǔ)研究, 2020M670027, 興奮性神經(jīng)元在阿爾茲海默癥中的功能研究, 2020-07 至 2022-02

參加科研項(xiàng)目：

  • 國(guó)家自然科學(xué)基金委員會(huì), 重大項(xiàng)目, 32394033, 孤獨(dú)癥腦發(fā)育異常的分子細(xì)胞機(jī)制及潛在干預(yù)靶點(diǎn), 2024-01-01 至 2028-12-31
  • 國(guó)家自然科學(xué)基金委員會(huì), 重點(diǎn)項(xiàng)目, 32130024, 中心粒的精細(xì)結(jié)構(gòu)及其調(diào)控機(jī)制, 2022-01-01 至 2026-12-31
  • 科技部, 國(guó)家重點(diǎn)研發(fā)計(jì)劃, 2017YFA0105200, 基于重大神經(jīng)疾病非人靈長(zhǎng)類模型的干細(xì)胞治療評(píng)價(jià)研究, 2017-07 至 2022-12

探索在病理情況（特別是自閉癥ASDs和阿爾茨海默病AD）下大腦神經(jīng)環(huán)路的變化。在之前的工作中，利用雙光子體在體成像技術(shù)，發(fā)現(xiàn)ASD小鼠模型的初級(jí)視覺(jué)皮層和AD小鼠的前額葉皮層的神經(jīng)環(huán)路功能存在缺陷。在未來(lái)，計(jì)劃運(yùn)用清醒狀態(tài)下的雙光子在體成像技術(shù)研究神經(jīng)精神疾病動(dòng)物模型的神經(jīng)環(huán)路的時(shí)空特性，尋找疾病的神經(jīng)環(huán)路機(jī)制。

主要研究論文

Li Y#, Tian Y#, Pei X#, Zheng P, Miao L, Li L, Luo C, Zhang P, Jiang B, Teng J*, Huang N*, Chen J*. (2023). l. SCG10 is required for peripheral axon maintenance and regeneration in mice. J Cell Sci. 136(12):jcs260490.(#co-first authors)

Su F#, Tian Y#*. (2022) Non-rigid Registration for Two-photon Imaging Using Triangulation and Piecewise Affine Transformation. Neuroscience. 491:1-12.(#co-first authors) (*corresponding authors)

Yang C#, Tian Y#, Su F#, Wang Y#, Liu M#, Wang H#, Cui Y#, Yuan P, Li X, Li A, Gong H, Luo Q, Zhu D, Cao P, Liu Y, Wang X, Luo MH, Xu F, Xiong W, Wang L, Li XY, Zhang C*. (2021) Restoration of FMRP expression in adult V1 neurons rescues visual deficits in a mouse model of fragile X syndrome. Protein Cell. 13(3):203-219. (#co-first authors)

Wang Y#, Su F#, Wang S#, Yang C#, Tian Y#, Yuan P#, Liu X, Xiong W*, Zhang C*. (2019) Efficient implementation of convolutional neural networks in the data processing of two-photon in vivo imaging. Bioinformatics.35(17):3208-3210. (#co-first authors)

Tian Y#, Yang C#, Cui Y#, Su F#, Wang Y#, Wang Y#, Yuan P, Shang S, Li H, Zhao J, Zhu D, Tang S, Cao P, Liu Y, Wang X, Wang L, Zeng W, Jiang H, Zhao F, Luo M, Xiong W, Qiu Z*, Li XY*, Zhang C*. (2018) An Excitatory Neural Assembly Encodes Short-Term Memory in the Prefrontal Cortex. Cell Reports. 22(7):1734-1744. (#co-first authors)

Tian Y#, Yang C#, Shang S#, Cai Y#, Deng X#, Zhang J, Shao F, Zhu D, Liu Y, Chen G, Liang J*, Sun Q*, Qiu Z*, Zhang C*. (2017) Loss of FMRP Impaired Hippocampal Long-Term Plasticity and Spatial Learning in Rats. Frontiers in Molecular Neuroscience.10:269. (#co-first authors)

合作發(fā)表論文

Wei M, Huang X, Liao L, Tian Y, Zheng X. (2023). SENP1 Decreases RNF168 Phase Separation to Promote DNA Damage Repair and Drug Resistance in Colon Cancer. Cancer Res. 83(17):2908-2923.

Lu K, Li C, Liu J, Wang J, Li Y, He B, Li J, Zhang X, Wei M, Tian Y, Zhang R, Zhang C, & Zhang Y. (2023). Impairments in endogenous AMPA receptor dynamics correlates with learning deficits in Alzheimer's disease model mice.Proc Natl Acad Sci U S A. 120(40), e2303878120.

Du L, Li J, Tian Y, Feng R. (2023). Pleckstrin-2-promoted PPM1B degradation plays an important role in transforming growth factor-β-induced breast cancer cell invasion and metastasis. Cancer Sci. 114(6):2429-2444.

Jiang LX, Huang GD, Tian YL, et al. (2023). Diminished activation of excitatory neurons in the prelimbic cortex leads to impaired working memory capacity in mice. BMC Biol. 21(1):171.

Zhao Y, Huang X, Zhu D, Wei M, Luo J, Yu S, Tian Y, Zheng X. (2022) Deubiquitinase OTUD6A promotes breast cancer progression by increasing TopBP1 stability and rendering tumor cells resistant to DNA-damaging therapy. Cell Death and Differentiation. 2022 Jun 29. doi: 10.1038/s41418-022-01036-6.

Ma D, Wang F, Wang R, Hu Y, Chen Z, Huang N, Tian Y, Xia Y, Teng J, Chen J. (2022) α-/γ-Taxilin are required for centriolar subdistal appendage assembly and microtubule organization. Elife. 11:e73252.

Zhu D, Xu R, Huang X, Tang Z, Tian Y, Zhang J, Zheng X. (2021) Deubiquitinating enzyme OTUB1 promotes cancer cell immunosuppression via preventing ER-associated degradation of immune checkpoint protein PD-L1. Cell Death and Differentiation. 28(6):1773-1789.

Xu R, Yu S, Zhu D, Huang X, Xu Y, Lao Y, Tian Y, Zhang J, Tang Z, Zhang Z, Yi J, Zhu HH, Zheng X. (2019) hCINAP regulates the DNA-damage response and mediates the resistance of acute myelocytic leukemia cells to therapy. Nature Communications.10(1):3812.

Zhou K, Ding Y, Vuletic I, Tian Y, Li J, Liu J, Huang Y, Sun H, Li C, Ren Q, Lu Y. (2018) In vivo long-term investigation of tumor bearing mKate2 by an in-house fluorescence molecular imaging system. Biomedical Engineering Online. 17(1):187.

Ji Y, Yang C, Tang Z, Yang Y, Tian Y, Yao H, Zhu X, Zhang Z, Ji J, Zheng X. (2017) Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation. Nature Communications. 8:15308.

Zeng WB, Jiang HF, Gang YD, Song YG, Shen ZZ, Yang H, Dong X, Tian YL, Ni RJ, Liu Y, Tang N, Li X, Jiang X, Gao D, Androulakis M, He XB, Xia HM, Ming YZ, Lu Y, Zhou JN, Zhang C, Xia XS, Shu Y, Zeng SQ, Xu F, Zhao F, Luo MH. (2017) Anterograde monosynaptic transneuronal tracers derived from herpes simplex virus 1 strain H129. Molecular Neurodegeneration. 12(1):38.

Yu J, Ju Y, Zhao L, Chu X, Yang W, Tian Y, Sheng F, Lin J, Liu F, Dong Y, Hou Y. (2016) Multistimuli-Regulated Photochemothermal Cancer Therapy Remotely Controlled via Fe5C2 Nanoparticles. ACS Nano. 10(1):159-69.

Bai D, Zhang J, Li T, Hang R, Liu Y, Tian Y, Huang D, Qu L, Cao X, Ji J, Zheng X. (2016) The ATPase hCINAP regulates 18S rRNA processing and is essential for embryogenesis and tumour growth. Nature Communications.7:12310.

Weng R, Shen S, Burton C, Yang L, Nie H, Tian Y, Bai Y, Liu H. (2016) Lipidomic profiling of tryptophan hydroxylase 2 knockout mice reveals novel lipid biomarkers associated with serotonin deficiency. Analytical and Bioanalytical Chemistry. 408(11):2963-73.

Weng R, Shen S, Tian Y, Burton C, Xu X, Liu Y, Chang C, Bai Y, Liu H. (2015) Metabolomics Approach Reveals Integrated Metabolic Network Associated with Serotonin Deficiency. Scientific Reports. 5:11864.

Weng R, Shen S, Yang L, Li M, Tian Y, Bai Y, Liu H. (2015) Lipidomic analysis of p-chlorophenylalanine-treated mice using continuous-flow two-dimensional liquid chromatography/quadrupole time-of-flight mass spectrometry. Rapid Communications in Mass Spectrometry. 2015 Aug 30;29(16):1491-500.

Zhong W, Zhu H, Sheng F, Tian Y, Zhou J, Chen Y, Li S, Lin J. (2014) Activation of the MAPK11/12/13/14 (p38 MAPK) pathway regulates the transcription of autophagy genes in response to oxidative stress induced by a novel copper complex in HeLa cells. Autophagy. 10(7):1285-300.

Shen H, Zhu H, Song M, Tian Y, Huang Y, Zheng H, Cao R, Lin J, Bi Z, Zhong W. (2014) A selenosemicarbazone complex with copper efficiently down-regulates the 90-kDa heat shock protein HSP90AA1 and its client proteins in cancer cells. BMC Cancer. 14:629.

Zhang Z, Jia C, Hu Y, Sun L, Jiao J, Zhao L, Zhu D, Li J, Tian Y, Bai H, Li R, Hu J. (2012) The estrogenic potential of salicylate esters and their possible risks in foods and cosmetics. Toxicology Letters. 209(2):146-53.