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王征實(shí)驗(yàn)室重點(diǎn)關(guān)注融合磁共振影像學(xué)、認(rèn)知決策計(jì)算、行為學(xué)、轉(zhuǎn)錄組學(xué)及神經(jīng)調(diào)控技術(shù)，探索精神疾病的量化診斷與個(gè)體化干預(yù)。研究特色在于構(gòu)建非人靈長類疾病模型，解析臨床情感認(rèn)知障礙類疾病的環(huán)路機(jī)制，研創(chuàng)神經(jīng)調(diào)控新技術(shù)開展認(rèn)知干預(yù)治療，開辟靈長類動(dòng)物模型向臨床轉(zhuǎn)化應(yīng)用的新途徑，推進(jìn)精神疾病的客觀診療。相關(guān)研究成果以資深或通訊作者身份發(fā)表在Science（2017）、Neuron(2013且同期配發(fā)專文點(diǎn)評(píng)、2018、2020、2022)、Nat Commun(2023)、Cell Discovery(2021)、Cell Reports(2023)、Am J Psychiatry（2021且同期配發(fā)專文點(diǎn)評(píng)）、Mol Psychiatry（2022）、J Neurol Neurosurgery Psychiatry (2021)、Biol Psychiatry (2016、2018，兩次同期配發(fā)專文點(diǎn)評(píng))、eLife（2022）、J Neurosci (2016、2020)、Cereb Cortex (2018、2021)、EBioMedicine(2017、2022)、IEEE TMI（2015）等國際主流學(xué)術(shù)期刊上。

目前聚焦的研究方向包括：

開展超高場(chǎng)靈長類磁共振成像與轉(zhuǎn)錄組學(xué)大數(shù)據(jù)研究，挖掘腦聯(lián)接圖譜的生物學(xué)基礎(chǔ)；

重點(diǎn)解析強(qiáng)迫癥、物質(zhì)成癮等情感認(rèn)知障礙類疾病的環(huán)路機(jī)制，建立影像學(xué)指標(biāo)評(píng)估優(yōu)化認(rèn)知行為、藥物以及深部腦刺激等治療方案的臨床療效；

利用基因編輯等多種技術(shù)手段建立靈長類動(dòng)物疾病模型，同時(shí)并行開展臨床研究（包括轉(zhuǎn)錄組學(xué)、行為學(xué)、影像學(xué)和神經(jīng)調(diào)控干預(yù)），探索模式動(dòng)物-人類臨床試驗(yàn)相互的轉(zhuǎn)化路徑，發(fā)展跨物種智能算法輔助的精準(zhǔn)診斷和治療。

Mapping brain connectomics in nonhuman primates offers a cutting-edge path to advance our understanding of neural networks, especially as we aim to translate these insights into human brain health applications. By integrating multi-modal approaches—such as MRI/PET imaging, genetic and transcriptomic profiling, behavioral analysis, and computational modeling—this line of our research has the potential to unveil intricate connections and functions within the brain that correlate with behavior, genetic traits, and disease vulnerabilities:

Zhang Z¹, Huang YC¹, Chen XY, Li JH, Yang Y, Lv LB, Wang JH, Wang MY*, Wang YW*, Wang Z*, State-specific regulation of electrical stimulation in the intralaminar thalamus of macaque monkeys: network and transcriptional insights into arousal, Advanced Science, 2024, 11(33): e2402718.

Wang W¹, Bo TT¹, Zhang G¹, Li J, Ma JJ, Ma LX, Hu GL, Tong HG, Lv Q, Daniel JA, Luo D, Chen YJ, Wang MY, Wang Z*, Wang G.-Z.*, Noncoding transcripts are linked to brain resting-state activity in non-human primates, Cell Reports, 2023, 42: 112652.

Bo TT¹, Li J¹, Hu GL, Zhang G, Wang W, Lv Q, Zhao SL, Qin M, Yao XH, Wang MY*, Wang GZ*, Wang Z*., Brain-wide and cell-specific transcriptomic insights into MRI-derived cortical morphology in macaque monkeys, Nature Communications, 2023, 14:1499.

Yan MC¹, Yu WW¹, Lv Q, Lv QM, Bo TT, Chen XY, Liu YL, Zhan YF, Yan SY, Shen XY, Yang BF, Hu QM, Yu JL, Qiu ZL, Feng YJ, Zhang XY, Wang H, Xu FQ, Wang Z*, Mapping brain-wide excitatory projectome of primate prefrontal cortex at submicron resolution and comparison with diffusion tractography, eLife, 2022, 11: e72534.

The PRIMatE Data and Resource Exchange (PRIME-DRE) Global Collaboration Workshop and Consortium, Toward next-generation primate neuroscience: a collaboration-based strategic plan for integrative neuroimaging, Neuron, 2022, 110: 1-5.

Zhan YF¹, Wei JZ¹, Liang J, Xu X, He R*, Robbins TW, Wang Z.*, Diagnostic classification for human autism and obsessive-compulsive disorder based on machine learning from a primate genetic model, American Journal of Psychiatry, 2021, 178(1): 65-76. [Commentary by van den Heuvel OA, Can transgenic monkeys help us innovate transdiagnostic therapies? American Journal of Psychiatry, 2021, 178(1): 8-10. Kalin NH, Genes, cells, and neural circuits relevant to OCD and autism spectrum disorder, American Journal of Psychiatry, 2021, 178(1): 1-4]

Qin DD¹, Zhou JK¹, He XC¹, Shen XY¹, Li C, Chen HZ, Yan LZ, Hu ZF, Li X, Lv LB, Yao YG*, Wang Z.*, Huang XX*, Hu XT*, Zheng P*, Depletion of giant ANK2 in monkeys causes drastic brain volume loss, Cell Discovery, 2021, 7(1):113. 

Lv QM, Yan MC, Shen XY, Wu J, Yu WW, Yan SY, Yang F, Zeljic K, Shi YQ, Zhou ZF, Lv LB, Hu XT, Menon R, Wang Z.*, Normative analysis of individual brain differences based on a population MRI-based atlas of cynomolgus macaques, Cerebral Cortex, 2021, 31(1): 341-355.

Wang XD, Li XH, Cho JW, Russ B, Rajamani N, Omelchenko A, Ai L, Korchmaros A, Sawiak S, Benn A.R., Garcia-Saldivar P, Wang Z, Kalin NH, Schroeder CE, Craddock RC, Fox AS, Evans AC, Messinger A, Milham MP, Xu T*, U-Net model for brain extraction: trained on humans for transfer to non-human primates, NeuroImage, 2021, 235:118001.

Cai DC¹, Wang ZW¹, Bo TT¹, Yan SY¹, Liu YL, Liu ZW, Zeljic K, Chen XY, Zhan YF, Xu X, Du YS, Wang YW, Cang J, Wang GZ, Zhang J, Sun Q, Qiu ZL, Ge SJ*, Ye Z, Wang Z.*, MECP2 duplication causes aberrant GABA pathways, circuits and behaviors in transgenic monkeys: neural mappings to patients with autism, Journal of Neuroscience, 2020, 40(19): 3799-3814.

The PRIMatE Data Exchange (PRIME-DE) Global Collaboration Workshop and Consortium, Accelerating the evolution of nonhuman primate neuroimaging, Neuron, 2020, 105: 600-602

Pu R, Wu Z, Yu WW, He HJ*, Zhou ZF, Wang Z*, Zhong JH, Association of myelination in the internal capsule with iron deposition in the basal ganglia in macaques: a magnetic resonance imaging study, Quantitative Imaging in Medicine and Surgery, 2020, 10(7):1526-1539.  

Zhang Z¹, Cai DC¹, Wang ZW, Zeljic K, Wang Z*, Wang YW*, Isoflurane-induced burst suppression increases intrinsic functional connectivity of the monkey brain, Frontiers in Neuroscience, 2019, 13: 296. doi: 10.3389/fnins.2019.00296.

Cui Y, Li X, Zeljic K, Shan S, Qiu Z*, Wang Z*, Effect of PEGylated magnetic PLGA-PEI nanoparticles on primary hippocampal neurons: reduced nano-neurotoxicity and enhanced transfection efficiency with magnetofection, ACS Applied Materials & Interfaces, 2019, 11(41): 38190-38204.

Milham MP, Ai L, Koo B, Xu T, Amiez C, Balezeau F, Baxter MG, Blezer ELA, Brochier T, Chen AH, Croxson PL, Damatac CG, Dehaene S, Everling S, Fair D, Fleysher L, Freiwald W, Froudist-Walsh S, Griffiths TD, Guedj C, Hadj-Bouziane F, Hamed SB, Harel N, Hiba B, Jarraya B, Jung B, Kastner S, Klink PC, Kwok SC, Laland K.N., Leopold DA, Lindenfors P, Mars RB, Menon RS, Messinger A, Meunier M, Mok K, Morrison JH, Nacef J, Nagy J, Rios MO, Petkov CI, Pinsk M, Poirier C, Procyk E, Rajimehr R, Reader SM, Roelfsema PR, Rudko D, Rushworth MFS, Russ B, Sallet J, Schmid M, Schwiedrzik CM, Seidlitz J, Sein J, Shmuel A, Sullivan EL, Ungerleider L, Thiele A, Todorov OS, Tsao D, Wang Z, Wilson CRE, Yacoub E, Ye F, Zarco W, Zhou YD, Margulies DS, Schroeder C, An open resource for nonhuman primate imaging, Neuron, 2018, 100:1-14.

Zhou TT¹, Zhu H¹, Fan ZX, Wang F, Chen Y, Liang HX, Yang ZF, Zhang L, Lin LN, Zhan Y, Wang Z, Hu H*, History of winning remodels thalamo-PFC circuit to reinforce social dominance, Science, 2017, 357: 162-168.

Lv Q¹, Yang LQ¹, Li GL, Wang ZW, Shen ZM, Yu WW, Jiang QY, Hou BY, Pu J, Hu H*, Wang Z.*, Large-scale persistent network reconfiguration induced by ketamine in anesthetized macaques: relevance to mood disorders, Biological Psychiatry, 2016, 79: 765-775. [Commentary by Arnsten AF, Murray JD, Seo H, and Lee D. Ketamine’s antidepressant actions: potential mechanisms in the primate medial prefrontal circuits that represent aversive experience, Biological Psychiatry, 2016, 79: 713-715]

Wang Z¹., Chen LM¹, Negyessy L¹, Friedman RM, Mishra A, Gore JC*, Roe AW*, The relationship of anatomical and functional connectivity to resting state connectivity in primate somatosensory cortex, Neuron, 2013, 78:1116-1126. [Previews by Olaf Sporns and Christopher J Honey, “Topographic dynamics in the resting brain”, 78, 955-956] 

Wang Z., Qi H-X, Kaas JH, Roe AW, Chen LM, Functional signature of recovering cortex: dissociation of local field potentials and spiking activity in somatosensory cortices of spinal cord injured monkeys, Experimental Neurology, 2013, 249:132-143.

Our research on human brain disorders began through a collaboration with clinical doctors in China, focusing on the therapeutic mechanisms of various neuroimaging and neuromodulation techniques, including deep brain stimulation. We aim to uncover the underlying effects of these techniques on patients and establish theoretical guidelines to improve treatment efficacy for individuals. Analyzing MRI data poses a unique challenge, prompting the development of new AI-derived computational models and algorithms to extract rich information on brain structure and function across diverse conditions.

Zhao SL¹, Lv Q¹, Zhang G, Zhang JT, Wang HQ, Zhang JM, Wang MY*, Wang Z*, Quantitative expression of latent disease factors in individuals associated with psychopathology dimensions and treatment response, Neuroscience Bulletin, 2024, advance online.

Yao JY, Li ZH, Zhou ZH, Bao AM, Wang Z*, Wei HJ*, He HJ*, Distinct regional vulnerability to Aβ and iron accumulation in postmortem AD brains, Alzheimer's & Dementia, 2024, 20(10): 6984-6997.

Liang H, Luo HR, Sang ZL, Jia M, Jiang XH, Wang Z, Cong S*, Yao XH*, GREMI: an explainable multi-omics integration framework for enhanced disease prediction and module identification, IEEE Journal of Biomedical and Health Informatics, 2024, 28(11): 6983-6996.

Cong S, Wang H, Zhou Y, Wang Z, Yao XH*, Yang CS*, Comprehensive review of Transformer-based models in neuroscience, neurology and psychiatry, Brain-X, 2024, 2: e57-e89.

Lv Q*, Zeljic K, Zhao SL, Zhang JT, Zhang JM, Wang Z*, Dissecting psychiatric heterogeneity and comorbidity with core region-based machine learning, Neuroscience Bulletin, 2023, 39(8):1309-1326.

Lv Q¹, Zhang M¹, Jiang HF¹, Liu YL, Zhao SL, Xu XM, Zhang WL, Chen TZ, Su H, Zhang JT, Wang HQ, Zhang JM, Feng YJ, Li YQ, Li B*, Zhao M*, Wang Z*, Metabolic and functional substrates of impulsive decision bias in abstinent heroin addicts after prolonged methadone maintenance treatment, NeuroImage, 2023, 283:120421.

Liu CC, Li KS, Zheng XX, Fu MN, Zhang YY, Sindermann C, Montag C, Wang Z, Zhou B, Kendrick K, Becker B, A central serotonin regulating gene polymorphism (TPH2) determines vulnerability to acute tryptophan depletion-induced anxiety and ventromedial prefrontal threat reactivity in healthy young men, European Neuropsychopharmacology, 2023, 77: 24-34.

Chen XY¹, Wang Z¹, Lv Q, Lv QM, van Wingen G, Fridgeirsson EA, Denys D, Voon V, Wang Z*, Common and differential connectivity profiles of deep brain stimulation and capsulotomy in refractory obsessive-compulsive disorder, Molecular Psychiatry, 2022, 27(2):1020-1030.

Li G, Huang P*, Cui SS, Tan YY, He YC, Shen X, Jiang QY, Huang P, He GY, Li BY, Li YX, Xu J, Wang Z*, Chen SD*, Mechanisms of motor symptom improvement by long-term Tai Chi training in Parkinson’s disease patients, Translational Neurodegeneration, 2022, 11: 6-16.

Zhang M¹, Qin QK¹, Zhang SN, Liu W, Meng HP, Xu MY, Huang XY, Lin XZ, Lin M, Herman P, Hyder F, Stevens RC, Wang Z, Li B*, Thompson GJ*, Aerobic glycolysis imaging of epileptic foci during the inter-ictal period, eBioMedicine, 2022, 79:104004.

Feng L¹, Yin DZ¹, Wang XB, Xu YF, Xiang YS, Teng F, Pan YG, Zhang XL, Su JH, Wang Z*, Jin LJ*, Brain connectivity abnormalities and treatment-induced restorations in patients with cervical dystonia, European Journal of Neurology, 2021, 28(5):1537-1547.

Hong J¹, Bo TT¹, Xi LQ¹, Xu XQ¹, He NY¹, Zhan YF, Li WY, Liang PW, Chen YF, Shi J, Yan FH, Gu WQ, Wang WQ, Liu RX, Wang JQ*, Wang Z*, Ning G, Reversal of functional brain connectivity associated with gut microbiome and gastrointestinal hormones after vertical sleeve gastrectomy in obese patients, Journal of Clinical Endocrinology & Metabolism, 2021, 106(9): e3619-e3633.

Zhang CC¹, Kim S-G¹, Li J, Zhang YY, Lv QM, Zeljic K, Gong HF, Zhan SK, Lin GZ, Sun BM*, Wang Z*, Voon V*., Anterior limb of the internal capsule tractography: relationship with capsulotomy outcomes in obsessive-compulsive disorder, Journal of Neurology, Neurosurgery and Psychiatry, 2021, 92(6):637-644.

Lv Q¹, Lv QM¹, Yin DZ, Zhang CC, Sun BM, Voon V*, Wang Z*, Neuroanatomical substrates and predictors of response to capsulotomy in intractable obsessive-compulsive disorder, Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2021, 28(5):1537-1547.

Zeljic K¹, Xiang Q¹, Wang ZW, Pan YY, Shi YQ, Zhou ZF, Wang Z*, Liu DT*, Heightened perception of illusory motion is associated with symptom severity in Schizophrenia patients, Progress in Neuropsychopharmacology & Biological Psychiatry, 2021, 104:110055.

Su H¹, Liu YL¹, Yin DZ, Chen TZ, Li XT, Zhong N, Jiang HF, Wang JJ, Du J, Xiao K, Xu D, Zeljic K, Wang Z*, Zhao M*, Neuroplastic changes in resting-state functional connectivity after rTMS intervention for methamphetamine craving, Neuropharmacology, 2020, 175: 108177

Su H¹, Chen TZ¹, Zhong N, Jiang HF, Du J, Xiao K, Xu D, Wang Z, Zhao M*, GABA and Glutamate/glutamine alterations of the left prefrontal cortex in individuals with methamphetamine use disorder: a combined TMS-MRS study, Annals of Translational Medicine, 2020, 8(6): 347-356.

Li HF¹, Yang LQ¹, Yin DZ¹, Chen WJ, Liu GL, Ni W, Wang N, Yu WW, Wu ZY*, Wang Z.*, Associations between neuroanatomical abnormalities and motor symptoms in paroxysmal kinesigenic dyskinesia, Parkinsonism & Related Disorders, 2019, 62:134-140.

Yin DZ, Chen XY, Zeljic K, Zhan YF, Shen XY, Yan G, Wang Z.*, Topological architecture of functional diversity of brain regions and its association with human intelligence, Brain and Behavior, 2019,9:e01358.

Yin DZ, Zhang Z, Wang ZW, Zeljic K, Lv Q, Cai DC, Wang YW, Wang Z.*, Brain map of intrinsic functional flexibility in anesthetized monkeys and awake humans, Frontiers in Neuroscience, 2019, 13:174. doi: 10.3389/fnins.2019.00174.

Wang ZW, Zeljic K, Jiang QY, Gu Y, Wang W, Wang Z*, Dynamic network communication in the human functional connectome predicts perceptual variability in visual illusion, Cerebral Cortex, 2018, 28(1):48-62.

Yin DZ¹, Zhang CC¹, Lv QM, Chen XY, Zeljic K, Gong HF, Jin HY, Wang Z.*, Sun BM*, Dissociable frontostriatal pathways: mechanism and predictor of the clinical efficacy of capsulotomy in obsessive-compulsive disorder, Biological Psychiatry, 2018, 84(12): 926-936. [Commentary by Hoexter MQ, Are we ready for individualized target planning of ablative procedures in intractable obsessive-compulsive disorder? Biological Psychiatry, 2018, 84(12): e85-e87]

Chen XY¹, Zhang CC¹, Li YX¹, Lv Q, Zeljic K, Huang P, Jin HY, Chen SD, Sun BM*, Wang Z.*, Functional connectivity-based modelling simulates subject-specific network effects of focal brain stimulation, Neuroscience Bulletin, 2018, 34(6):921-938.

Yin DZ¹, Liu WJ¹, Wang ZW, Zeljic K, Bo TT, Lv Q, You MN, Men WW, Fan MX, Cheng WH*, Wang Z*., Failure in cognitive suppression of negative affect in adolescents with generalized anxiety disorder, Scientific Reports, 2017, 7:6583, doi:10.1038/s41598-017-07063-5.

Lv QM¹, Wang Z¹, Zhang CC¹, Fan Q, Zeljic K, Sun BM, Xiao ZP*, Wang Z.*, Divergent structural responses to pharmacological interventions in orbitofronto-striato-thalamic and premotor circuits in obsessive-compulsive disorder, eBioMedicine, 2017, 22:242-248.

Pan YX¹, Wang LJ¹, Wang ZW¹, Xu C, Yu WW, Spillmann L, Gu Y*, Wang Z.*, Wang W*. Representations of illusory and real rotations in human MST– a cortical site for the Pinna illusion, Human Brain Mapping, 2016, 37: 2097-2113.

Yin DZ, Liu WJ, Zeljic K, Wang ZW, Lv Q, Fan MX, Cheng WH*, Wang Z*, Dissociable changes of frontal and parietal cortices in inherent functional flexibility across the human lifespan, Journal of Neuroscience, 2016, 36(39):10060-10074.

Pu J, Wang J, Yu WW, Shen ZM, Lv Q, Zeljic K, Zhang CC, Sun BM, Liu GX, Wang Z.*. Discriminative structured feature engineering for macroscale brain connectomes, IEEE Trans Med Imaging, 2015, 34(11):2333-2342.